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:: Volume 17, Number 9 (12-2014) ::
amuj 2014, 17(9): 1-10 Back to browse issues page
Studying the Antibacterial Effect of Polyamidoamine-G4 Dendrimer on Some of the Gram-Negative and Gram-Positive Bacteria
Hassan Izanloo, Mohammad Ahmadi Jebelli, Shahram Nazari, Navid Safavi, Hamid Reza Tashayoe, Gharib Majidi , Mohammad Khazaei, Vahid Vaziri Rad, Behnam Vakili, Hussein Aghababaei
MSc, School of Public Health, Qom University of Medical Sciences, Qom, Iran , gharibmajidi@gmail.com
Abstract:   (3419 Views)

Background: This study aimed to examine the antibacterial effect of Polyamidoamine-G4 dendrimer on Escherichia coli, Enterobacter cloacae, Bacillus subtilis and Staphylococcus aureus.

Materials and Methods: In this experimental study, the antibacterial effects of Polyamidoamine-G4 dendrimer were studied by disc diffusion and micro-dilution method. Different concentrations of Polyamidoamine-G4 inoculated onto blank disks and were placed in Mueller-Hinton agar media. Zone of inhibition was investigated by bacterial inoculation according to the McFarland standard 0.5. Minimum inhibitory concentration and minimum bactericidal concentration of Polyamidoamine-G4 dendrimer were determined by micro-dilution method in nutrient broth culture.

Results: Zone of inhibition in concentration 500 &mug/ml of Polyamidoamine-G4 dendrimers for Escherichia coli, Enterobacter cloacae, Bacillus subtilis and Staphylococcus aureus were 14, 0, 35 and 29mm, respectively. Concerning the Zone of inhibition in gram negative bacteria with gram positive ones was p<0.05 and had significant difference. The minimum inhibitory concentration of Polyamidoamine-G4 dendrimer for Escherichia coli, Bacillus subtilis and Staphylococcus aureus were 1250, 2.5, and 1 &mug/ml, respectively. The minimum bactericidal concentration of Polyamidoamine-G4 dendrimer belonged to Escherichia coli, Bacillus subtilis and Staphylococcus aureus were 2500, 5 and 5 &mug/ml, respectively. Polyamidoamine-G4 dendrimer had not bacteriostatic and bactericidal effects on Enterobacter cloacae.

Conclusion: According to the results, Polyamidoamine-G4 dendrimer can eliminate Escherichia coli, Staphylococcus aureus and Bacillus subtilis effectively. It is suggested in the rest of this study that the probable toxicity of nanostructured compounds examined in drinking water and, economic studies is done for synthesis and their applications in case of prevention of using.

Keywords: Poly(amidoamine), Anti-bacterial agents, Minimum bactericidal concentration, Minimum bactericidal concentration, Zone of inhibition
Full-Text [PDF 743 kb]   (743 Downloads)    
Type of Study: Original Atricle | Subject: Health
Received: 2014/06/29 | Accepted: 2014/11/19 | Published: 2014/11/19
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Izanloo H, Ahmadi Jebelli M, Nazari S, Safavi N, Tashayoe H R, Majidi G, et al . Studying the Antibacterial Effect of Polyamidoamine-G4 Dendrimer on Some of the Gram-Negative and Gram-Positive Bacteria. amuj. 2014; 17 (9) :1-10
URL: http://amuj.arakmu.ac.ir/article-1-3042-en.html
Volume 17, Number 9 (12-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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