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:: Volume 17, Issue 8 (11-2014) ::
AMUJ 2014, 17(8): 63-70 Back to browse issues page
Antinociceptive Effect of Brassica Juncea on Peripheral Neuropathy Induced by Diabetes in Rat
Ali Gomar , Abdolkarim Hosseini , Naser Mirazi , Mojtaba Gomar
Assistant Professor, Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University , khosseini32@alumni.ut.ac.ir
Abstract:   (3167 Views)

Background: Diabetes mellitus is a common metabolic disorder that is associated with many complications such as peripheral neuropathies. This study was designed to investigate the effect of Brassica juncea on peripheral neuropathic pain in diabetic rat.

Materials and Methods: In this experimental study, male Wistar rats (250±20 g) were divided randomly to normal and diabetic (control, B. juncea extract at doses 150 and 300 mg/kg) groups. Experimental diabetes was induced by the intraperitoneal injection of streptozotocin (60 mg/kg). After four weeks treatment, animals were subjected to Tail-flick test to evaluate pain threshold and data were analyzed using SPSS software. Statistical significance was considered at p<0.05.

Results: The results of this study showed that diabetes significantly decreased pain threshold in the rats. Also diabetes-induced hyperalgesia was significantly decreased by treatment with extracts of B. juncea at doses 150 and 300 mg/kg (p<0.05 and p<0.01, respectively).

Conclusion: Our observation indicates that B. juncea could be a therapeutic option for control and treatment of hyperalgesia associated with diabetic neuropathy in diabetic patients. However, further studies are required to elucidate the antinociceptive effects of B. juncea.

Keywords: Brassica juncea, Diabetes, Diabetic neuropathy, Pain, Streptozotocin
Full-Text [PDF 710 kb]   (694 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2014/06/26 | Accepted: 2014/08/26 | Published: 2014/10/22
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Gomar A, Hosseini A, Mirazi N, Gomar M. Antinociceptive Effect of Brassica Juncea on Peripheral Neuropathy Induced by Diabetes in Rat. AMUJ. 2014; 17 (8) :63-70
URL: http://amuj.arakmu.ac.ir/article-1-3035-en.html

Volume 17, Issue 8 (11-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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