Volume 17, Issue 7 (10-2014)                   J Arak Uni Med Sci 2014, 17(7): 41-47 | Back to browse issues page

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Khoshbakht T, Soosanabadi M, Karimlou M, Neishaboury M, Khorram Khorshid H R. Association Study of IL16 Gene Polymorphism with the Risk of Sporadic Alzheimer’s Disease. J Arak Uni Med Sci. 2014; 17 (7) :41-47
URL: http://amuj.arakmu.ac.ir/article-1-2958-en.html
Professor, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran , hrkk1@uswr.ac.ir
Abstract:   (4400 Views)

Background: Interleukin-16 (IL16) is an important regulator of T cell activation and was reported to act as achemo-attractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer’s disease (AD). This study was performed to show whether the IL-16 genepolymorphism, rs11556218 is associated with the risk of sporadic AD in Iranian population.

Materials and Methods: Totally, 148 AD patients and 137non-dementia controls were recruited in this case-control study. Genotyping of rs11556218 T/Gpolymorphism was performed by PCR-RFLP method using the NdeI restriction enzyme.

Results: Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16(0.1-0.28)). Frequency of rs11556218 allele T was higher in patients than controls (p=0.001, OR=0.32(0.21-0.49)).

Conclusion: Our results indicate thatrs11556218 polymorphism has a protective role in the development of sporadic AD in Iranian population.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2014/05/18 | Accepted: 2014/07/28 | Published: 2014/09/22

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