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:: Volume 17, Number 7 (10-2014) ::
amuj 2014, 17(7): 41-47 Back to browse issues page
Association Study of IL16 Gene Polymorphism with the Risk of Sporadic Alzheimer’s Disease
Tayyebeh Khoshbakht, Mohsen Soosanabadi, Masoud Karimlou, Maryem Neishaboury, Hamid Reza Khorram Khorshid
Professor, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran , hrkk1@uswr.ac.ir
Abstract:   (3795 Views)

Background: Interleukin-16 (IL16) is an important regulator of T cell activation and was reported to act as achemo-attractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer’s disease (AD). This study was performed to show whether the IL-16 genepolymorphism, rs11556218 is associated with the risk of sporadic AD in Iranian population.

Materials and Methods: Totally, 148 AD patients and 137non-dementia controls were recruited in this case-control study. Genotyping of rs11556218 T/Gpolymorphism was performed by PCR-RFLP method using the NdeI restriction enzyme.

Results: Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16(0.1-0.28)). Frequency of rs11556218 allele T was higher in patients than controls (p=0.001, OR=0.32(0.21-0.49)).

Conclusion: Our results indicate thatrs11556218 polymorphism has a protective role in the development of sporadic AD in Iranian population.

Keywords: Alzheimer’s disease, Association study, IL16, Polymorphism
Full-Text [PDF 518 kb]   (746 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2014/05/18 | Accepted: 2014/07/28 | Published: 2014/09/22
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Khoshbakht T, Soosanabadi M, Karimlou M, Neishaboury M, Khorram Khorshid H R. Association Study of IL16 Gene Polymorphism with the Risk of Sporadic Alzheimer’s Disease. amuj. 2014; 17 (7) :41-47
URL: http://amuj.arakmu.ac.ir/article-1-2958-en.html
Volume 17, Number 7 (10-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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