[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 13, Issue 1 (4-2010) ::
AMUJ 2010, 13(1): 90-96 Back to browse issues page
The protective effect of green tea extract on acetaminophen induced nephro-toxicity in mice
Masumeh Abdolahi , Laya Khordandi , Khadije Ahrari
M.Sc of Midwifery , val_asr@yahoo.com
Abstract:   (11177 Views)
Background: Green tea, which is the most common drink in the world, has antioxidant and detoxification properties. In this study, the protective effect of green tea extract on nephro-toxicity induced by acetaminophen was investigated. Materials and Methods: 32 male mice were randomly divided into 4 groups. Physiologic serum was administered to the control group for 30 days. Toxic (Acetaminophen) group received physiologic serum for 30 days and on day 30 in addition to physiologic serum, 500 mg/kg acetaminophen was administered orally. Green tea group, instead of water, was fed by 7g/l green tea extract for 30 days. Instead of water, the experiment green tea group was fed with green tea extract for 30 days and 500 mg/kg oral acetaminophen was administered on day 30. On day 31, blood samples were taken from jugular arteries for assaying BUN and Cr. The mice kidneys were cut off and placed in 10% formalin for histopathology assessments. Results: BUN and Cr reduced significantly in the experiment group in comparison with the toxic group. Also, in histopathology assessments, kidney necrosis reduced in experimental group. Conclusion: Green tea seems to have a protective role in acetaminophen induced nephro-toxicity.
Keywords: Acetaminophen, green tea, nephro-toxicity
Full-Text [PDF 431 kb]   (2046 Downloads)    
Subject: Basic Sciences
Received: 2009/03/31
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Abdolahi M, Khordandi L, Ahrari K. The protective effect of green tea extract on acetaminophen induced nephro-toxicity in mice. AMUJ. 2010; 13 (1) :90-96
URL: http://amuj.arakmu.ac.ir/article-1-270-en.html

Volume 13, Issue 1 (4-2010) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
Persian site map - English site map - Created in 0.061 seconds with 803 queries by yektaweb 3619