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:: Volume 9, Number 3 (9-2006) ::
amuj 2006, 9(3): 36-43 Back to browse issues page
Protective effect of Plantago Psyllium seed on contractile reactivity of thoracic aorta of Streptozotocin-diabetic rats
Mehrdad Roghani , Tourandokht Balouchnejad, Samira Yadegari, Rouholah Miri
Assistant professore , mehjour@yahoo.com
Abstract:   (15677 Views)
Introduction: Considering the increasing incidence of atherosclerosis and cardiovascular disorders in diabetes mellitus, this study was conducted to evaluate the beneficial effect of two-month administration of Plantago Psyllium (PP) seed on the contractile reactivity of isolated aorta in diabetic rats. Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into four control, PP-treated control, diabetic and PP-treated diabetic groups. To induce diabetes, Streptozotcin (STZ) was intraperitoneally administered (60mg/Kg). PP-treated groups received PP mixed with standard pelleted food at a weight ratio of 6.25%. After 2 months, contractile reactivity of thoracic aortic rings to KCl and Noreadrenaline were determined using isolated tissue setup. Data was analyzed using ANOVA and Tukey tests. Results: Serum glucose level showed a significant increase in diabetic group after one and two months (p<0.001), but it,s decrease in PP-treated diabetic group was not significant in comparison to diabetic group. Also PP-treated diabetic group showed a lower contraction to KCl (p<0.05) and noreadrenaline (p<0.01) as compared to diabetic group. Meanwhile, there was no significant difference between control and PP-treated control groups regarding contractile reactivity. Conclusion: It can be concluded that oral administration of PP for 2 months can decrease the contractile responsiveness of vascular system and this may prevent the development of hypertension in diabetic rats.
Keywords: Plantago Psyllium, vascular system, diabetes mellitus, contractile response, rat
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Subject: General
Received: 2008/09/4
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Roghani M, Balouchnejad T, Yadegari S, Miri R. Protective effect of Plantago Psyllium seed on contractile reactivity of thoracic aorta of Streptozotocin-diabetic rats. amuj. 2006; 9 (3) :36-43
URL: http://amuj.arakmu.ac.ir/article-1-27-en.html
Volume 9, Number 3 (9-2006) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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