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:: Volume 17, Number 2 (5-2014) ::
amuj 2014, 17(2): 17-23 Back to browse issues page
Biochemical Evaluation of the Effects of Iranian Snake (Naja Naja Oxiana) Venom According to the Kidney Indices in Rabbit
Abbas Zaree mirakabadi, Abdolhamid Angaji, Adele Hooshmandi
Student of MSc, Department of Cellular and Moleclar Biology, College of Biosciences, Kharazmi University,Square of University, Hesarak, Karaj, Iran , adelehoo63@gmail.com
Abstract:   (3819 Views)

Background: One of the acute effects of snakebite is injury to vital organs including kidneys. This study examines the effects of snake (Najanajaoxiana) venom on renal function.

Materials and Methods: In this experimental study, six male Dutch rabbits with average weight of 1.5± 0.3 kg were selected. Before injection of the venom, blood samples were collected for serum analysis and then the snake (Najanajaoxiana) venom (140µg/kg) was injected intramuscularly. Following venom injection, blood sampling from each rabbit was carried out at hours 1, 3, and 24. All serum samples were separated within two hours and the amounts of creatinine, urea, albumin, and glucose were determined by quantitative detection kits. Statistical analyses were carried out by SPSS software version 21. Obtained information was compared by one-way ANOVA and F and Tukey tests. p value<0.05 was considered significant.

Results: Following venom injection at hours 1, 3, and 24, some serum parameters showed slight changes which were not statistically significant. However, glucose showed a significant increase (71%) at hour 1 (p<0.05). Following venom injection, this returned to normal at hour 24.

Conclusion: Based on the results obtained in the present study, it seems that the Najanajaoxiana venom, unlike the viper species, have no severe effects on the kidney.

Keywords: Kidney, Najanajaoxiana, Rabbit
Full-Text [PDF 572 kb]   (965 Downloads)    
Type of Study: Original Atricle | Subject: General
Received: 2013/11/26 | Accepted: 2014/03/5 | Published: 2014/04/20
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Zaree mirakabadi A, Angaji A, Hooshmandi A. Biochemical Evaluation of the Effects of Iranian Snake (Naja Naja Oxiana) Venom According to the Kidney Indices in Rabbit. amuj. 2014; 17 (2) :17-23
URL: http://amuj.arakmu.ac.ir/article-1-2659-en.html
Volume 17, Number 2 (5-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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