[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Number 10 (1-2014) ::
amuj 2014, 16(10): 11-18 Back to browse issues page
Improvement in Sperm Parameters with Gonadotropin-Releasing Hormone Analogue in Busulfan Treated Prepubertal Mice
Maryam Baazm , Mohammad Reza Darabi, Saeed Babaie, Reza Talebi
Assistant Professor, Department of anatomy, Arak University of Medical Sciences, Arak, Iran , dr.baazm@arakmu.ac.ir
Abstract:   (6050 Views)

Background: One of the side effects of chemotherapy agents is gonadal suppression leading to infertility. The present study examined the feasibility of using a gonadotropin releasing hormone agonist (GnRH-A) in the prevention of busulfan induced azoospermia in prepubertal mice.

Materials and Methods: In this case and control research, Leuprolide (3.8 mg/kg) was given to prepubertal male mice 2 weeks after or prior to busulfan (40 mg/kg) administration. The animals received one or two doses of leuprolide after busulfan administration with 4 weeks apart. Six weeks after the last leuprolide treatment, the sperm parameters were analyzed icluded sperm count and motility according to the World Health Organization criteria.

Results: At the time of scarifies, testicular weight were increased in animals receiving leuprolide. In animals receiving leuprolide pretreatment, the percentage of progressive and immotile sperm was significantly (p&le0.05) increased and decreased respectively. But the percentage of non progressive sperm did not change. The sperm motility in busulfan treated animals with post treatment didn't change. The sperm count also increased in pretreatment animals but it was not significant (p&ge0.05).

Conclusion: The present study demonstrates that leuprolide pretreatment resulted in improvement in sperm motility in prepubertal male mice.

Keywords: Busulfan, Chemotherapy, Leuprolide, Sperm parameters
Full-Text [PDF 463 kb]   (1131 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2013/08/18 | Accepted: 2013/11/20 | Published: 2013/12/18
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Baazm M, Darabi M R, Babaie S, Talebi R. Improvement in Sperm Parameters with Gonadotropin-Releasing Hormone Analogue in Busulfan Treated Prepubertal Mice . amuj. 2014; 16 (10) :11-18
URL: http://amuj.arakmu.ac.ir/article-1-2474-en.html
Volume 16, Number 10 (1-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
Persian site map - English site map - Created in 0.055 seconds with 793 queries by yektaweb 3505