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:: Volume 10, Number 4 (12-2007) ::
amuj 2007, 10(4): 64-73 Back to browse issues page
Comparing the effect of dietary administration of isomeric fatty acids on chemical kindling in second generation of Wistar kindled rats
Raza Mahdavi , Seyed Vali Razavieh, Mahmood reza Nakhai, Mahmood reza Palizvan
Associate professore , mahdavirez@hotmail.com
Abstract:   (13891 Views)
Introduction: Impressive research demonstrate the importance of essential fatty acids for many physiological and behavioral mechanisms in both humans and animals. Essential fatty acids must be supplied via the diet. In this study the dietary effect of cis and trans fatty acids on seizures induced by Pentylenetetrazol (PTZ) in second generation of rats is studied. Materials and Methods: In this experimental study animals were divided into four groups. In the three case groups cis, trans, or cis+trans fatty acids were added to the standard food of rats and in control group only standard food was dietary administrated. After one month, kindling was established in rats with PTZ in subconvulsive dose (45mg/kg i.p.). Convulsing activities were monitored for 20 minutes. Five stages of convulsing activities were observed. If after three consecutive sessions the animal was in the fifth stage, it was considered as a kindled animal. Data was analyzed using K-S, t, Tukey tests and analysis of variance. Results: Results showed that the convulsion stage in trans group was significantly more than the others. Also it was found that duration of the fifth stage in trans group was significantly more than control and cis groups. Conclusion: Results suggest that, administering sis and trans fatty acids have some effects on PTZ induced kindling in second generation of the rats who were kindled before. More severe seizure and longer duration of seizure was seen in trans group comparing to cis
Keywords: Pentylenetetrazol, kindling, cis fatty acid, trans fatty acid
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Subject: General
Received: 2009/03/11
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Mahdavi R, Razavieh S V, Nakhai M R, Palizvan M R. Comparing the effect of dietary administration of isomeric fatty acids on chemical kindling in second generation of Wistar kindled rats. amuj. 2007; 10 (4) :64-73
URL: http://amuj.arakmu.ac.ir/article-1-246-en.html
Volume 10, Number 4 (12-2007) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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