Volume 9, Issue 2 (6-2006)                   J Arak Uni Med Sci 2006, 9(2): 62-67 | Back to browse issues page

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Yazdi B, Jalali S M. Effect of Clonidine premedication on blood and urine electrolytes and urinary output. J Arak Uni Med Sci. 2006; 9 (2) :62-67
URL: http://amuj.arakmu.ac.ir/article-1-241-en.html
Assistant professore , yazdibijan@hotmail.com
Abstract:   (21935 Views)
Introduction: Clonidine, as a premedicant in anesthesia, has a special role in decreasing anesthetic agents' dose and improving sedation. Because of its effects on body hemodynamics and electrolytes and the importance of these effects during anesthesia, we decided to investigate these side effects in this study. Materials and Methods: This is a double blind randomized clinical trial. Samples were 104 ASA Class Ι & Π, 20-40 years old patients, undergoing elective surgery and were divided equally into two groups (case and control). 90 minutes before induction of anesthesia, 5μg/kg Clonidine was given to the case and placebo to the control group orally. Blood samples were taken before and 4 hours after induction of anesthesia. Also 24 hours urine was collected and measured for volume and sodium and potassium concentrations. Data analysis was done using independent T test. Results: There wasn’t any significant difference between two groups in the mean concentration of blood sodium and potassium before and after taking the drug. But the mean sodium and potassium concentration in urine was significantly more in the case group (P = 0.022 and P = 0.003 respectively). The volume of 24 hours urine was also more in the case group (P = 0.008). Conclusion: Although Clonidine induces diuresis and increases sodium and potassium excretion, blood concentration of these electrolytes doesn’t change significantly.
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Subject: General
Received: 2009/03/10

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