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:: Volume 16, Number 9 (12-2013) ::
amuj 2013, 16(9): 65-75 Back to browse issues page
Antidepressant-Like Effect of Aqueous and Hydroalcoholic Extracts of Lavandula Angustifolia Mill in Forced Swim Test and Tail Suspension Test in Male Mice
Saeid Abbasi Maleki , Reza Bekhradi, Jinous Asgharpanah, Farid Abbasi Maleki, Niloufar Maleki Ahanghari
Assistant Professor, Department of Pharmacology, Urmia Branch, Islamic Azad University, Urmia, Iran , dr.s.a.maleki@gmail.com
Abstract:   (10352 Views)

Background: Lavandula officinalis has anti-anxiety and sedative properties. In the present study, the antidepressant effect of aqueous and hydroalcoholic extracts of Lavandula officinalis in forced swim test (FST) and tail suspension test (TST) in male mice was investigated.

Materials and Methods: In this experimental study, 72 male mice were randomly divided into 9 groups of 8: Negative and positive control groups received normal saline (10 ml/kg), fluoxetine (20mg/kg) and imipramine (30mg/kg) respectively and treatment groups received extracts of Lavandula officinalis (100,200 and 400 mg/kg). Immobility, swimming and climbing behaviors were recorded during 6-min.

Results: Lavandula officinalis extracts (except the aqueous extract at a dose of 100 in FST) compared to control group significantly and dose dependently reduced the duration of immobility time a both of tests (p<0.001).Also, these extracts (except the aqueous extract at a dose of 100 in FST) significantly and dose dependably increased swimming time (p<0.001) without significant change of climbing time.

Conclusion: Lavandula officinalis has considerable antidepressant-like effect and their effect similar to fluoxetine.

Keywords: Lavandula angustifolia mill, Extract, Forced swim test, Tail suspension test, Mice
Full-Text [PDF 473 kb]   (2024 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2013/05/31 | Accepted: 2013/11/20 | Published: 2013/11/20
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Abbasi Maleki S, Bekhradi R, Asgharpanah J, Abbasi Maleki F, Maleki Ahanghari N. Antidepressant-Like Effect of Aqueous and Hydroalcoholic Extracts of Lavandula Angustifolia Mill in Forced Swim Test and Tail Suspension Test in Male Mice. amuj. 2013; 16 (9) :65-75
URL: http://amuj.arakmu.ac.ir/article-1-2343-en.html
Volume 16, Number 9 (12-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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