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:: Volume 17, Number 4 (7-2014) ::
amuj 2014, 17(4): 82-88 Back to browse issues page
Comparison between Antipyretic Effects of Acetaminophen and Ibuprofen Monotherapy with Alternative Regimen of Both Drugs in Children Aged 6 Months to 12 Years
Parsa Yousefichaijan, Mahdieh O Sadat Ghafari , Hasan Taher Ahmadi, Leila Farajzadeh, Azam Zamamiyan
SMc, Arak University of Medical Sciences, Arak, Iran , ghafari@arak mu.ac.ir
Abstract:   (3915 Views)

Background: Pediatricians frequently confront with elevated body temperature in children and subsequent anxious parents. They practice several approaches in management of fever. A recently addressed issue is administration of alternating doses of acetaminophen and Ibuprofen. This method is relatively common , despite lack of sufficient evidence in this field.

Materials and Methods: This study is a randomized clinical trial. A total of 240 children, aged 6 months to 12 years suffering from gastroenteritis was recruited in this research. Children were classified in 3 groups. First group received Acetaminophen, second group received Ibuprofen and third group were treated with acetaminophen – Ibuprofen every other day alternately.

Results: 240 child were taken apart in this research . 112 ones were female (46.66%) and 128 were male (53.33%). The mean time of lowering fever in the first group was 2.07 days. This figure in the second and third groups were 1.82 and 1.87 respectively. Average doses in the first, second and third groups were (in order) 9, 8.17 and 7.13 doses. Medication in the first group minimum effectiveness rather than two other groups.

Conclusion: The alternating regimen of Acetaminophen – Ibuprofen is more effective than monotherapy in reduction of fever in infants and children between 6 months to 12 years.

Keywords: Fever, Monotherapy, Alternative regimen therapy, Acetaminophen, Ibuprofen
Full-Text [PDF 199 kb]   (770 Downloads)    
Type of Study: Original Atricle | Subject: General
Received: 2013/05/19 | Accepted: 2014/05/7 | Published: 2014/06/21
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Yousefichaijan P, Ghafari M O S, Taher Ahmadi H, Farajzadeh L, Zamamiyan A. Comparison between Antipyretic Effects of Acetaminophen and Ibuprofen Monotherapy with Alternative Regimen of Both Drugs in Children Aged 6 Months to 12 Years. amuj. 2014; 17 (4) :82-88
URL: http://amuj.arakmu.ac.ir/article-1-2314-en.html
Volume 17, Number 4 (7-2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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