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:: Volume 16, Issue 6 (9-2013) ::
AMUJ 2013, 16(6): 14-21 Back to browse issues page
Effects of Crocus Sativus Petals Extract on Blood Parameters in Rat
Atefeh Babaei , Javad Arshami , Ali Reza Haghparast , Mohsen Danesh Mesgaran
MSc, Agriculture Faculty, Ferdowsi University of Mashhad, Iran , Atefeh_babaie@yahoo.com
Abstract:   (7425 Views)

Background: Saffron (Crocus Sativus) petals consist of, glycosides, flavonoids, and anthocyanins. Due to the increasing use of medicinal plants in treatment of diseases and identifying their side effects on various organs, this study is to evaluate the effects of Crocus Sativus petals on biochemical blood parameters in male rats.

Materials and Methods: In this experimental study, 30 male Wistar rats with the mean body weight of 215±15 g were randomly assigned into five groups of 6 animals each. Control group received normal saline (10 ml/kg) and treatment groups received 75, 150, 220 and 450 mg/kg body weight of saffron petals extract, for 14 days. Body weight measured in days 0, 7, and 14. At the end of experiment, serum levels of liver function marker enzymes such as AST and ALT, total proteins, albumin, creatinine, cholesterol and triglyceride were assessed.

Results: Compared to control group, ethanol extract of saffron petals significantly increased serum albumin and also significantly decreased levels of serum cholesterol and AST (p<0.05). No significant changes were observed on serum total proteins, creatinine, ALT, triglyceride levels and body weight in control and saffron groups (p>0.05).

Conclusion: Increase in levels of albumin and decrease in liver enzymes may indicate the lack of liver damage. Reduction in cholesterol which is probably due to flavonoid extracts of saffron and no effect on body weight can be beneficial in the use of saffron petals.   

Keywords: Blood lipids, Liver enzymes, Rat, Saffron petals
Full-Text [PDF 358 kb]   (1488 Downloads)    
Type of Study: Original Atricle | Subject: General
Received: 2013/02/24 | Accepted: 2013/09/14 | Published: 2013/09/14
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Babaei A, Arshami J, Haghparast A R, Danesh Mesgaran M. Effects of Crocus Sativus Petals Extract on Blood Parameters in Rat. AMUJ. 2013; 16 (6) :14-21
URL: http://amuj.arakmu.ac.ir/article-1-2195-en.html

Volume 16, Issue 6 (9-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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