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:: Volume 16, Number 6 (9-2013) ::
amuj 2013, 16(6): 51-64 Back to browse issues page
Synthesis and Physicochemical Evaluation of Nanosized Lamivudine Loaded PEGylated Chitosan
Hosein Heydari, Mehdi Shafiee Ardestani, Rezvan Zabihollahi, Seyed Mehdi Sadat, Shiva Irani, Seyed Nezamedin Hoseini, Safieh Amini, Seyed Davar Syadat, Mohammad Sadegh Khosravi, Alireza Azizi Saraji, Pouneh Rahimi, Mohammad Reza Aghasadeghi
Associate Professor, 6- Associate Professor, Department of Hepatitis and AIDS, Pasteur Institute, Tehran, Iran , mrasadeghi@pasteur.ac.ir
Abstract:   (10287 Views)

  Background: Due to the lack of efficient anti-HIV vaccine, anti-HIV pharmaceuticals play an important role in controlling HIV infection. Also significant rise in drug resistance and drug toxicity has caused increased interest in finding new anti-HIV agents. In this study, a nano-sized version of lamivudine based on PEGylated chitosan was synthesized.

  Materials and Methods: In this research, nanoparticles of chitosan were efficiently PEGylated for increasing their stability in water and then the anti-HIV drug, lamivudine, was loaded on these PEGylated nanoparticles. After purification and lyophilization of new synthesized nanoparticle, the raw materials and final product were sampled and FTIR, HNMR and CHN analyses were done.

  Results: Results of HNMR spectroscopy showed that chitosan nanoparticle was successfully PEGylated. HNMR data confirmed FTIR results and indicated that lamivudine was conjugated on chitosan nanoparticle. In addition, CHN analysis data also confirmed both HNMR and FTIR data, and demonstrated that a high yield of chitosan nanoparticle PEGylation (approximately 97%) was done and illustrated a high capacity of lamivudine conjugation on nano-sized PEGylated chitosan (30% W/W chitosan).

  Conclusion: In this study, lamivudine drug was successfully synthesized, based on PEGylated chitosan nanoparticle.

 

Keywords: anti-HIV agent, Chitosan, Lamivudine, Polyethylene glycols
Full-Text [PDF 1386 kb]   (10202 Downloads)    
Type of Study: Original Atricle | Subject: Infection
Received: 2013/01/19 | Accepted: 2013/09/14 | Published: 2013/09/14
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Heydari H, Shafiee Ardestani M, Zabihollahi R, Sadat S M, Irani S, Hoseini S N, et al . Synthesis and Physicochemical Evaluation of Nanosized Lamivudine Loaded PEGylated Chitosan. amuj. 2013; 16 (6) :51-64
URL: http://amuj.arakmu.ac.ir/article-1-2137-en.html
Volume 16, Number 6 (9-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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