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:: Volume 16, Number 6 (9-2013) ::
amuj 2013, 16(6): 65-71 Back to browse issues page
Association Study Between BAT1 Gene Variation and Late-Onset (Sporadic) Alzheimer’s Disease in Iranian Population
Mohsen Soosanabadi Farahani, Kourosh Kamali, Masoud Karimlou, Mehdi Banan, Hamid Reza Khorram Khorshid
Associate Professor 1. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran , hrkk1@uswr.ac.ir
Abstract:   (8676 Views)

Background: There is abundant evidence indicating that inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. BAT1, a member of the DEAD-box family of RNA helicases, appears to regulate the production of inflammatory cytokines associated with AD pathology. In the current study BAT1 -22 promoter polymorphism was analyzed in AD and control subjects.

Materials and Methods: In this case-control study, genomic DNA from peripheral blood samples of 153 Alzheimer’s patients and 153 healthy controls was extracted using salting-out method. DNA analysis was performed by PCR-RFLP method and p<0.05 was considered statistically significant.

Results: After genotyping and statistical analysis the results failed to show any association between BAT1 -22 promoter polymorphism and sporadic Alzheimer’s disease.

Conclusion: BAT1 -22 is not associated with Alzheimer’s disease in Iranian population and so has no effect on predisposition to sporadic Alzheimer’s disease.

Keywords: BAT1, PCR-RFLP, Alzheimer’s disease, Polymorphism
Full-Text [PDF 398 kb]   (1096 Downloads)    
Type of Study: Qulitative | Subject: Basic Sciences
Received: 2012/12/24 | Accepted: 2013/09/14 | Published: 2013/09/14
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Soosanabadi Farahani M, Kamali K, Karimlou M, Banan M, Khorram Khorshid H R. Association Study Between BAT1 Gene Variation and Late-Onset (Sporadic) Alzheimer’s Disease in Iranian Population. amuj. 2013; 16 (6) :65-71
URL: http://amuj.arakmu.ac.ir/article-1-2100-en.html
Volume 16, Number 6 (9-2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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