Volume 16, Number 6 (9-2013)                   amuj 2013, 16(6): 65-71 | Back to browse issues page


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Soosanabadi Farahani M, Kamali K, Karimlou M, Banan M, Khorram Khorshid H R. Association Study Between BAT1 Gene Variation and Late-Onset (Sporadic) Alzheimer’s Disease in Iranian Population. amuj. 2013; 16 (6) :65-71
URL: http://amuj.arakmu.ac.ir/article-1-2100-en.html

Associate Professor 1. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran , hrkk1@uswr.ac.ir
Abstract:   (8561 Views)

Background: There is abundant evidence indicating that inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. BAT1, a member of the DEAD-box family of RNA helicases, appears to regulate the production of inflammatory cytokines associated with AD pathology. In the current study BAT1 -22 promoter polymorphism was analyzed in AD and control subjects.

Materials and Methods: In this case-control study, genomic DNA from peripheral blood samples of 153 Alzheimer’s patients and 153 healthy controls was extracted using salting-out method. DNA analysis was performed by PCR-RFLP method and p<0.05 was considered statistically significant.

Results: After genotyping and statistical analysis the results failed to show any association between BAT1 -22 promoter polymorphism and sporadic Alzheimer’s disease.

Conclusion: BAT1 -22 is not associated with Alzheimer’s disease in Iranian population and so has no effect on predisposition to sporadic Alzheimer’s disease.

Full-Text [PDF 398 kb]   (1064 Downloads)    
Type of Study: Qulitative | Subject: Basic Sciences
Received: 2012/12/24 | Accepted: 2013/09/14 | Published: 2013/09/14

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