Volume 16, Issue 1 (4-2013)                   J Arak Uni Med Sci 2013, 16(1): 1-9 | Back to browse issues page

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Badkoobeh Hezaveh P, Parivar K, Kalantar S M, Salabat A, Hosseini S D. Protective Effect of Nano-Zinc Oxide on Reproductive System and Fertility of Adult Male Wistar Rats Following Doxorubicin Treatment. J Arak Uni Med Sci. 2013; 16 (1) :1-9
URL: http://amuj.arakmu.ac.ir/article-1-1882-en.html
Assistant Professor, Razi Vaccine and Serum Research Institute, Central Area Branch, Arak, Iran , Hosseinida@yahoo.com
Abstract:   (7681 Views)

Background: Doxorubicin (DOX) is a widely used anticancer drug, but its use in clinical chemotherapy is limited due to its side effects, including testicular toxicity. The aim of this study was to investigate the protective effect of nano-zinc oxide (nZnO) on DOX-induced reproductive toxicity in male rats.

Materials and Methods: In this experimental study, adult male Wistar rats were randomly divided into four groups, including one control and three experimental groups. They received saline, DOX (6 mg/kg), nZnO (5 mg/kg), and nZnO followed by DOX (i.p), respectively. Treatment was performed for 3 days. After 28 days, post-administration histological changes and reproductive indices were studied.

Results: Administration of DOX induced a significant reduction in seminiferous tubules diameter and thickness of germinal epithelium. Also, fertility and fecundity indices, number of litters and epididymal sperm concentration, decreased, whereas degenerated Leydig cells and deformed Sertoli cells increased.

Conclusion: Coadministration of nZnO significantly improved DOX-induced changes. These findings show the protective role of nZnO in DOX-induced reproductive toxicity.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2012/08/6 | Accepted: 2013/08/28 | Published: 2013/08/28

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