Volume 16, Number 1 (4-2013)                   amuj 2013, 16(1): 16-23 | Back to browse issues page


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Tadayon Najafabadi M, Shalikar Z, Adedi P, Bamshad Z. The Impact of Omega-3 Fatty Acids on Depression of Menopausal Women: A Randomized Double-Blind Clinical Trial. amuj. 2013; 16 (1) :16-23
URL: http://amuj.arakmu.ac.ir/article-1-1747-en.html

MSc, Department of Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , zahra.shalikar_m@yahoo.com
Abstract:   (7339 Views)

Background: Depression is one of the most commonly observed problems in menopausal women. This study was conducted to determine the effect of omega-3 fatty acids on menopausal depression in women referring to No. 1 Health Clinic of Ahvaz, Iran, in 2010.

Materials and Methods: This randomized double-blind clinical trial was done on 70 menopausal women experiencing various levels of depression. After administering the Hamilton Depression Rating Scale (HAM-D-21), the participants who met the inclusion criteria were randomly divided into intervention group (n=35) receiving a 2gr omega-3 capsules and control group (n=35) receiving 2 gr placebo capsules. After 8 weeks of intervention, data were collected and analyzed by Chi-square, independent t-test, and one-way ANOVA with repeated measures using SPSS software version 17.

Results: Mean depression scores decreased significantly (p<0.001) in the intervention group (13.36±2.23 to 8.72±3.71). Also, mean depression scores decreased (p>0.05) in the control group (13.25±2.04 to 11.78±2.93) however, it was not significant. The comparison of depression scores did not indicate a significant difference regarding the reduction of depression after intervention between the two groups (p=0.08).

Conclusion: According to the findings of this study, administration of omega-3 capsules (2gr/daily) for 8 weeks decreased menopausal depression. However, there was not a significant difference between omga-3 and placebo groups in this study. For a more precise observation of the effects, further studies with longer periods of intervention are needed.

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Type of Study: Original Atricle | Subject: Obstetrics & Gynocology
Received: 2012/06/13 | Accepted: 2013/08/28 | Published: 2013/08/28

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