Volume 15, Issue 4 (September 2012)                   AMUJ 2012, 15(4): 34-39 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shojapuor M, Mosayebi G, Ghasami K, Ghazavi A, Sadeghi A. Vitamin D receptor gene polymorphism in patients with multiple sclerosis in Mar kazi Province. AMUJ. 2012; 15 (4) :34-39
URL: http://amuj.arakmu.ac.ir/article-1-1287-en.html
Arak University of Medical Sciences , sadegha@arakmu.ac.ir
Abstract:   (9961 Views)
Background: Multiple sclerosis (MS) is an autoimmune disease which demyelinates the central nervous system. Vitamin D, is a potential environmental factor which influences this disease. The majority of the biological activities of the polymorphism forms of vitamin D are done through its receptor gene (VDRG). The aim of this study was to examine the relationship between BsmI polymorphisms in VDRG and the incidence of MS. Materials and Methods: In this case-control study, the BsmI polymorphism in the VDRG was studied in 80 Iranian MS patients and 50 healthy controls of the same genetic background and age through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method Results: There was a significant difference in the frequency of BsmI VDRG polymorphism genotypes between MS patients and controls (P=0.023). Conclusion: This study indicated that the VDRG BsmI polymorphism is associated with MS in this population.
Full-Text [PDF 296 kb]   (2065 Downloads)    
Subject: Basic Sciences
Received: 2011/08/23

Add your comments about this article : Your username or Email:
Write the security code in the box

Send email to the article author


© 2018 All Rights Reserved | Arak Medical University Journal

Designed & Developed by : Yektaweb