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:: Volume 15, Number 4 (September 2012) ::
amuj 2012, 15(4): 40-46 Back to browse issues page
Study of polymorphism frequency of 1639G> A gene from VKORC1 in patients with cardiovascular disorders in the northwestern area of Iran
Seyed Mahmoud Tabatabaei, Amir Monfaredan , Nasrin Bargahi, Shahram Dabiri Oskuei
- - , amir.monfaredan@yahoo.com
Abstract:   (7541 Views)
Background: In addition to known environmental and acquired factors effective in cardiovascular diseases, polymorphisms of VKORC1 and CYP2C9 genes are identified as the main genetic factors involved in warfarin dosage requirement variations in these patients. With this approach, investigating the frequency of 1639 G>A in VKORC1 gene for determining the specific dosage required for each person was the main aim of this study. Materials and Methods: In this experimental study, peripheral blood samples were obtained from 200 patients with cardiovascular disorders in the northwestern areas of Iran (West and East Azarbayjan and Ardabil) and RFLP-PCR technique was used to determine the 1639G> A polymorphism of VKORC1. Results: Using Hardy-Weinberg law‏, polymorphism amounts of 1639G> A gene from VKORC1 in female and male patients with normal, heterozygote, and homozygote were determined 21.6%, 53.7%, 24.5% , and 22.3%, 60.6%, and 17.02% , respectively. Conclusion: VKORC1 genotyping is one of the important parameters that together with other confounding factors reduce the role of trial and error in patients with cardiovascular diseases. Genotypic variety and the high frequency of allele A in the studied population can justify varied responses to warfarin therapy and the importance of investigation before starting treatment with warfarin.
Keywords: Optimum dosage, Polymorphism, Warfarin
Full-Text [PDF 208 kb]   (1363 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2011/04/12 | Accepted: 2011/11/2
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Tabatabaei S M, Monfaredan A, Bargahi N, Dabiri Oskuei S. Study of polymorphism frequency of 1639G> A gene from VKORC1 in patients with cardiovascular disorders in the northwestern area of Iran. amuj. 2012; 15 (4) :40-46
URL: http://amuj.arakmu.ac.ir/article-1-1111-en.html
Volume 15, Number 4 (September 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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