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:: Volume 14, Number 7 (Brucellosis Supplement 2012) ::
amuj 2012, 14(7): 78-84 Back to browse issues page
The effect of the administration of corticosteroid on the treatment of patients with brucellosis
Afsaneh Karami, Ahmadreza Mobaien , Manizheh Jozpanahi, Masomeh Sarokhani
1. Assistant prof. of infectious diseases Zanjan University of medical sciences , amobaien@yahoo.com
Abstract:   (7427 Views)
Background: Brucellosis is an endemic disease in Iran and its treatment is a medical problem. This study was performed to observe the influence of the administration of corticosteroid on symptomatology of subjects with acute, subacute, and chronic brucellosis. Materials and Methods: In this randomized controlled trial, 48 patients with brucellosis were randomly assigned to two groups. The first group (N=30) received the standard regimen plus dexamethasone (4 mg t.d.s for 5 days) and the second group (N=17) received only the standard regimen. The results of corticosteroid administration were evaluated according to such factors as clinical status of the patient, duration of hospital stay, duration of illness, pain score, and use of analgesics. The results were analyzed by Chi-square test, Fisher’s exact test, independent sample t-test, and Mann-Whitney test. Results: No significant differences were seen in the mean of hospital stay, duration of illness, and use of oral and injectable analgesics between the two groups (P<0.05). Also, there was not a significant difference in mean pain score reduction between groups 1 and 2 (P<0.05). Conclusion: Noticing the findings of this study, corticosteroid does not seem to alter the clinical course of brucellosis significantly. Nevertheless, further controlled clinical trials with larger sample sizes are recommended
Keywords: Brucellosis, Corticosteroid, Outcome
Full-Text [PDF 1804 kb]   (1130 Downloads)    
Subject: Infection
Received: 2011/02/26 | Accepted: 2011/08/20
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Karami A, Mobaien A, Jozpanahi M, Sarokhani M. The effect of the administration of corticosteroid on the treatment of patients with brucellosis. amuj. 2012; 14 (7) :78-84
URL: http://amuj.arakmu.ac.ir/article-1-1072-en.html
Volume 14, Number 7 (Brucellosis Supplement 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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