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:: Volume 20, Issue 9 (12-2017) ::
AMUJ 2017, 20(9): 45-56 Back to browse issues page
Study the Effect of Crocin on Avoidance Memory and Motor Activity Impairment Induced by Doxorubicin Administration in Adult Male Rats
Javad Sohrabi Asadabad , Zohreh Ghotbeddin , Mohammad Reza Tabandeh
Assistant Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. , z.ghotbeddin@scu.ac.ir
Abstract:   (2186 Views)
Abstract
Background: A lot of studies indicate that cancer chemotherapy drugs such as doxorubicin results in memory impairment. On the other hand, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor enhancement. So, in this work, we have studied the co-administration effect of crocin and doxorubicin on avoidance memory and motor activity in adult male rat.
Material and Methods: In this study, 50 male rats were divided into 5 groups: control, sham, doxorubicin, crocin and treated rats with coadministration of doxorubicin and crocin. In crocin group, crocin injected 30mg/kg for 21 days and each rat in the chemotherapy group was treated once a week for 3 weeks with doxorubicin (5mg/kg). Treatment group, received doxorubicin and crocin at the same time. Sham groups administrated with saline. All drugs were injected intraperitoneally. After these procure passive avoidance memory, balance and exploratory behaviors were assessed respectively by shuttle box, rotarod and open field instruments.
Results: Memory in rats which have consumed doxorubicin significantly was decreased compared to other groups (p<0.001). Crocin treatment improved memory impairment following doxorubicin injection (p<0.001). Motor activity in open field and rotarod tests in treatment group showed significantly increased compared to doxorubicin group (p<0.001).
Conclusion: Crocin consumption beside of anticancer drugs such as doxorubicin has protective effect on the bad effects of chemotherapy drugs on memory and movement.

 
Keywords: Avoidance memory, Crocin, Doxorubicin, Motor activity, Rat
Full-Text [PDF 1257 kb]   (524 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2017/10/9 | Accepted: 2017/11/5 | Published: 2017/11/21
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Sohrabi Asadabad J, Ghotbeddin Z, Tabandeh M R. Study the Effect of Crocin on Avoidance Memory and Motor Activity Impairment Induced by Doxorubicin Administration in Adult Male Rats. AMUJ. 2017; 20 (9) :45-56
URL: http://amuj.arakmu.ac.ir/article-1-5366-en.html


Volume 20, Issue 9 (12-2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اراک Arak Medical University Journal
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