Volume 20, Issue 12 (3-2018)                   J Arak Uni Med Sci 2018, 20(12): 51-62 | Back to browse issues page

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Azimi F, Siahkouhian M, Seifi-Skishahr F, Afroundeh R. Study The Effect of 4 weeks of Special Aerobic Training on CBS and SAM Levels in Hippocampus of Rats with Alzheimer-induced Disease with Aβ1-42 Injection. J Arak Uni Med Sci. 2018; 20 (12) :51-62
URL: http://amuj.arakmu.ac.ir/article-1-5463-en.html
Professor of Sport Physiology, Department of Physical Education and Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran. , marefat_siahkuhian@yahoo.com
Abstract:   (675 Views)
Background: H2S plays a key role in the pathogenesis of the Alzheimer’s disease. The aim of the present study was to investigate the effects of 4 weeks of the special aerobic training after induction of Alzheimer’s disease by Aβ1-42 injection on CBS and SAM levels in hippocampus of Wistar male rats.
Materials and Methods: Twenty male Wistar rats (8 weeks old and weight 195 ± 20 g) were divided into four groups including: healthy control, Alzheimer’s control, Alzheimer’s + training and sham. To induce Alzheimer’s disease, Aβ1-42 was infused into the hippocampus of rats. Training group trained for 4-week. For data analysis, one-way ANOVA was used and Eta and Omega squared tests were used to determine the effect size (p<0.05).
Results: Findings revealed that 4 weeks of special aerobic training increased significantly the CBS and SAM levels in hippocampus of Alzheimer’s rats compared to the control Alzheimer’s rats ( ES=53; p= 0.007, ES= 92.22; p= 0.001). Also, we showed 4 weeks of special aerobic training increased CBS level in hippocampus of Alzheimer’s rats compared to the healthy cotrol group (ES= 44.07;
p= 0.014).
Conclusion: It seems that the special aerobic training can be used as a useful non-pharmacologically effective therapeutic treatment for Alzheimer's patients through positive regulation of hydrogen sulfide via CBS and SAM enzymes.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2017/11/21 | Accepted: 2018/01/17 | Published: 2018/02/14

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